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Why you should purify solvents with a filter prior to use in Chromatography

Purifying solvents with a filter prior to use in chromatography is an essential step that cannot be ignored. Solvents used in chromatography are usually of high purity, but it's not uncommon for them to contain impurities that can cause a number of problems.


Impurities in solvents can lead to poor separation, reduced column life, and increased baseline noise, among other issues.

Here are the top 5 issues you may face:

1. Poor separation: If impurities are present in your solvent, they can interfere with the separation of your sample components, resulting in poor resolution and overlapping peaks.

2. Reduced column life: Impurities in your solvent can cause damage to the column packing material, leading to a shorter lifespan for your column.

3. Increased baseline noise: Impurities can cause background noise in your chromatogram, making it difficult to accurately analyze your sample.

4. Contaminated samples: If your solvent contains impurities, it can contaminate your sample, leading to inaccurate results and wasted time and resources.

5. Safety concerns: Some impurities can be hazardous to your health or the environment, so it's important to ensure that your solvents are as pure as possible to minimize any potential risks.

By taking the simple step of purifying your solvents with a filter prior to use in chromatography analysis, you can avoid these issues and ensure that the solvent is of the highest possible purity this will result in better chromatographic separations. It's a simple step that can make a big difference in the quality of your chromatography. Don't overlook this important step!

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